RNA Vaccine History

[tmcom]

Thought that l should do a report on RNA technology to just see the good, bad and ugly, and not what the blind leading the blind tell us.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421

This is a paper for the SARS virus in 2012, and why it was, (all vaccines, including DNA altering) not flagged for humans.

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Four candidate vaccines for humans with or without alum adjuvant were evaluated in a mouse model of SARS, a VLP vaccine, the vaccine given to ferrets and NHP, another whole virus vaccine and an rDNA-produced S protein. Balb/c or C57BL/6 mice were vaccinated IM on day 0 and 28 and sacrificed for serum antibody measurements or challenged with live virus on day 56. On day 58, challenged mice were sacrificed and lungs obtained for virus and histopathology.

They all showed promise in animal trails, but where abandoned due to increasing the like hood of hypersensitivity in the future with different SARS strains.

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These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.

And this is what Lung Immunopathology means, (Google).

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Lung immunopathology refers to exaggerated inflammation that envelopes the gas-exchanging units of the lung after viral infection and which may interfere with oxygenation. It is a concern because it can lead to worse disease than what would normally be seen after virus infection in the complete absence of vaccination.

This is why oxygen may need to be administered after the host is injected with the Pfizer, AZ or other widely used Covid vaccines, presently available.

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An early concern for application of a SARS-CoV vaccine was the experience with other coronavirus infections which induced enhanced disease and immunopathology in animals when challenged with infectious virus

Or in other words, take the Pfizer vac, and any variants that that vaccine cannot protect against, and they will be worse in the host, at least until a vaccine is developed to cover said SARS or COVID variant.

They also ran a stronger test, to confirm the first, with this noteworthy exert.

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Of interest is that those given live virus and then challenged with live virus two months later exhibited an infiltrative disease severity comparable to the PBS and vaccinated groups despite no detectable virus on day two, again suggesting some degree of infection may have occurred earlier.

So for example the Pfizer vaccine will protect you for a short time, but future variants will be more severe, as well as it being virtually impossible for a corporation to anticipate all variants and get it out to the host fast enough, (the yearly flu shot picks the three worst variants only).

And differences in lung structure were obvious, or non injected lung structures where vastly different to injected.

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This effort was hampered by the occurrence in the initial preclinical trial of an immunopathogenic-type lung disease among ferrets and Cynomolgus monkeys given a whole virus vaccine adjuvanted with alum and challenged with infectious SARS-CoV [14]. That lung disease exhibited the characteristics of a Th2-type immunopathology with eosinophils in the lung sections suggesting hypersensitivity that was reminiscent of the descriptions of the Th2-type immunopathologic reaction in young children given an inactivated RSV vaccine and subsequently infected with naturally-occurring RSV [32]–[33]. Most of these children experienced severe disease with infection that led to a high frequency of hospitalizations; two children died from the infection

So modern emergency use, Covid vaccines will protect for a short while against one strain, (and its variants) of Covid, but could lead to certain lung diseases, and an increase in hypersensitivity to future strains.

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In addition to the RSV experience, concern for an inappropriate response among persons vaccinated with a SARS-CoV vaccine emanated from experiences with coronavirus infections and disease in animals that included enhanced disease among infected animals vaccinated earlier with a coronavirus vaccine

Thus, all four vaccines evaluated induced the immunopathology; however, all four also induced neutralizing antibody and protection against infection when compared to control challenged animals.

This is why this line of research was abandoned, since the host gets protected but the tradeoff of more susceptibility and worse future symptions was too high.

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Because of well documented severity of the respiratory disease among infants given an inactivated RSV vaccine and subsequently infected with RSV that is considered to be attributable to a Th2-type immunopathologic reaction and a large number of studies in the Balb/c mouse model that have described and elucidated many components of the immunopathologic reaction to RSV vaccines, the similarity to the SARS-CoV vaccine evaluations in Balb/c mice supports caution for clinical vaccine trials with SARS-CoV vaccines in humans.

https://www.the-scientist.com/news-opinion/the-promise-of-mrna-vaccines-68202

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The concept of using mRNA to produce useful proteins to fight disease has been around for decades. But until now, no vaccines using this technology have made it this far in clinical trials.

Despite its promise, there are challenges associated with working with mRNA. Ordinary mRNA produces only low levels of proteins, and the molecule degrades too quickly inside the body to make it suitable as a therapeutic. On top of that, RNA can trigger an immune response that’s independent of the response to the protein it encodes.

They go on further by saying that they have suppressed this response.

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Ultimately, it’s too early to say why these vaccines so far appear to work so well. “These do remain interim results.

Remember that word, interim, or the results So Far are encouraging, but Doctors just don't know about long term.

And now we get to the Ugly.

https://www.bbc.com/future/article/20200505-cytokine-storms-when-the-body-attacks-itself

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Variants on this hyperactive immune reaction occur in an array of conditions, triggered by infection, faulty genes or autoimmune disorders in which the body thinks its own tissues are invaders.

This is a real, potential outcome of Pfizer and the rest of the RNA based drugs, where the body attacks a virus and then notices the virus in its vital organs.

The rest of the article goes on about this occurring in Covid patients not people who have been vaccinated, even though all preceding evidence tells us it is a real possibility.

If Pfizer, AstraZeneca and the like didn't have Emergency Use, they wouldn't have seen the light of day, and long term health affects are unknown at this time, or in other words, they, (like all vaccines in the past) need 7 to 15 years before deemed safe).

 

High vitamin D intake is enough to stave off hospitalization globally from Covid-19, and not a series of vaccines, were long term health affects are a 100% complete unknown.

 

PS l am not a physician of any kind, but go by experts which are and have videos on this forum.